Description:
AbstractHerein, we report a new one‐pot synthesis of polysubstituted carbazoles starting from β‐nitro‐β,γ‐unsaturated‐ketones and indoles. The process is based on a Friedel‐Crafts reaction of indoles to nitroolefins supported by 2,2,2‐trifluoroethanol (TFE) followed by an acidic‐promoted and microwave‐assisted intramolecular cyclization, that involves the elimination of both nitrous acid and water molecules. Products were obtained in satisfactory to good overall yields (55–78%).