Cytogenetic and molecular characterization of a patient with simultaneous B‐cell chronic lymphocytic leukemia and peripheral T‐cell lymphoma

Media type: E-Article
Title: Cytogenetic and molecular characterization of a patient with simultaneous B‐cell chronic lymphocytic leukemia and peripheral T‐cell lymphoma
Contributor: Martin‐Subero, J. Ignacio; Siebert, Reiner; Harder, Lana; Gesk, Stefan; Schwindt, Peter; Bräuninger, Andreas; Willenbrock, Klaus; Steinemann, Doris; Tiemann, Markus; Calasanz, Maria Jose; Grote, Werner; Ludwig, Wolf‐Dieter; Hansmann, Martin‐Leo; Schlegelberger, Brigitte
imprint: Wiley, 2001
Published in: American Journal of Hematology
Language: English
DOI: 10.1002/ajh.1190
ISSN: 0361-8609; 1096-8652
Keywords: Hematology
Origination:
Footnote:
Description: <jats:title>Abstract</jats:title><jats:p>A patient is described who developed a peripheral T‐cell lymphoma (PTCL) after a 6‐year history of B‐cell chronic lymphocytic leukemia (B‐CLL). The progression of the T‐cell disease spreading to pleura and skin terminated the course of the disease. A cytogenetic analysis performed six years after the first onset of the B‐CLL showed the presence of two clones, one with trisomy 12 and another with inv(14)(q11q32.1) and trisomy 8. Combined immunophenotyping and fluorescence <jats:italic>in situ</jats:italic> hybridization demonstrated that only CD19+ cells contained a trisomy 12, whereas CD3+ cells contained a trisomy 8. Analyses of IgH and TCR rearrangements in single micromanipulated B‐ and T‐cells lacked evidence for a clonal relation between B‐CLL and PTCL cells. Based on our findings, we discuss the different hypotheses which might explain the development of simultaneous PTCL and B‐CLL. Am. J. Hematol. 68:276–279, 2001. © 2001 Wiley‐Liss, Inc.</jats:p>
Access State: Open Access

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