Description:
<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Previous studies indicate that 30% to 40% of all Alzheimer’s disease (AD) cases are attributable to modifiable risk factors. In addition to cardiovascular risk factors also stress and sleep disturbances have been identified as risk factors (Escher et al. 2019; Sindi et al. 2018). Here, we report results from the cross‐sectional Individual risk profiling for Alzheimer’s disease and dementia prevention (INSPIRATION) study and provide a detailed overview on the frequency and distribution of AD risk factors.</jats:p></jats:sec><jats:sec><jats:title>Method</jats:title><jats:p>The cross‐sectional assessment of healthy study participants (aged 50 or older) included established and self‐developed questionnaires and physical examination. We inquired about demographics, medical history, family history, physical activity, diet, BMI, hearing loss, presence of depression, anxiety, stress, resilience, and loneliness. In addition, we performed neuropsychological testing (CERAD+) and blood sampling for genetic testing.</jats:p></jats:sec><jats:sec><jats:title>Result</jats:title><jats:p>Results in 162 participants showed a mean age of 64.6 years (50‐86 years), mean education years of 16.3 (10‐20) and a mean MMST score of 29.5 (26‐30). Moreover, 63% were female, 49% were retired, 51% were part‐ or full‐time employed and 70% had at least one relative with dementia.</jats:p><jats:p>The four most frequent lifestyle risk factors were non‐adherence to Mediterranean diet in 69% of subjects, obesity in 49% with a mean BMI of 25.8 kg/m2 (16.1‐41.6kg/m2sleep disturbances in 52% and reduced resilience in 23% of the subjects. Concerning pre‐existing diagnoses known to increase AD risk, the four most frequent were hypercholesterinemia (50%), a thyroid disease (36%), hypertension (34%) and vitamin deficiency (33%).</jats:p><jats:p>A preliminary analysis of ApoE ε4 status for n = 123 participants revealed that 32.5% were heterozygotes; the remaining 67.5% were non‐carriers. The full set of assessed risk factors will be presented.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The results of the INSPIRATION study aid to understand the prevalence and distribution of a large number of modifiable AD risk factors in a community‐dwelling sample. The data will be used to develop a tool box of interventions for personalized strategies to prevent AD in a population which is particularly interested in dementia prevention.</jats:p></jats:sec>