Ubiquilin 1 polymorphisms are not associated with late‐onset Alzheimer's disease

Media type: E-Article
Title: Ubiquilin 1 polymorphisms are not associated with late‐onset Alzheimer's disease
Contributor: Smemo, Scott; Nowotny, Petra; Hinrichs, Anthony L.; Kauwe, John S. K.; Cherny, Sara; Erickson, Katherine; Myers, Amanda J.; Kaleem, Mona; Marlowe, Lauren; Gibson, Alison M.; Hollingworth, Paul; O'Donovan, Michael C.; Morris, Chris M.; Holmans, Peter; Lovestone, Simon; Morris, John C.; Thal, Leon; Li, Yonghong; Grupe, Andrew; Hardy, John; Owen, Michael J.; Williams, Julie; Goate, Alison
imprint: Wiley, 2006
Published in: Annals of Neurology
Language: English
DOI: 10.1002/ana.20673
ISSN: 0364-5134; 1531-8249
Keywords: Neurology (clinical) ; Neurology
Origination:
Footnote:
Description: <jats:title>Abstract</jats:title><jats:p>Several studies have reported evidence for linkage of late‐onset Alzheimer's disease (LOAD) to chromosome 9. Recently, an intronic polymorphism affecting alternative splicing of exon 8 of ubiquilin 1 (UBQLN1) was reported to be associated with LOAD. We attempted to replicate this observation by genotyping this polymorphism, rs12344615 (also known as UBQ‐8i), in a large sample of 1,544 LOAD cases and 1,642 nondemented controls. We did not find any evidence that this single nucleotide polymorphism, or any of six others tested in <jats:italic>UBQLN1</jats:italic>, increases risk for LOAD. Ann Neurol 2005</jats:p>

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