Meta‐analysis of Parkinson's Disease: Identification of a novel locus, RIT2

Media type: E-Article
Title: Meta‐analysis of Parkinson's Disease: Identification of a novel locus, RIT2
Contributor: Pankratz, Nathan; Beecham, Gary W.; DeStefano, Anita L.; Dawson, Ted M.; Doheny, Kimberly F.; Factor, Stewart A.; Hamza, Taye H.; Hung, Albert Y.; Hyman, Bradley T.; Ivinson, Adrian J.; Krainc, Dmitri; Latourelle, Jeanne C.; Clark, Lorraine N.; Marder, Karen; Martin, Eden R.; Mayeux, Richard; Ross, Owen A.; Scherzer, Clemens R.; Simon, David K.; Tanner, Caroline; Vance, Jeffery M.; Wszolek, Zbigniew K.; Zabetian, Cyrus P.; Myers, Richard H.; [...]
imprint: Wiley, 2012
Published in: Annals of Neurology
Language: English
DOI: 10.1002/ana.22687
ISSN: 0364-5134; 1531-8249
Keywords: Neurology (clinical) ; Neurology
Origination:
Footnote:
Description: <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective:</jats:title><jats:p>Genome‐wide association (GWAS) methods have identified genes contributing to Parkinson's disease (PD); we sought to identify additional genes associated with PD susceptibility.</jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p>A 2‐stage design was used. First, individual level genotypic data from 5 recent PD GWAS (Discovery Sample: 4,238 PD cases and 4,239 controls) were combined. Following imputation, a logistic regression model was employed in each dataset to test for association with PD susceptibility and results from each dataset were meta‐analyzed. Second, 768 single‐nucleotide polymorphisms (SNPs) were genotyped in an independent Replication Sample (3,738 cases and 2,111 controls).</jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p>Genome‐wide significance was reached for SNPs in <jats:italic>SNCA</jats:italic> (rs356165; G: odds ratio [OR] = 1.37; <jats:italic>p</jats:italic> = 9.3 × 10<jats:sup>−21</jats:sup>), <jats:italic>MAPT</jats:italic> (rs242559; C: OR = 0.78; <jats:italic>p</jats:italic> = 1.5 × 10<jats:sup>−10</jats:sup>), <jats:italic>GAK/DGKQ</jats:italic> (rs11248051; T: OR = 1.35; <jats:italic>p</jats:italic> = 8.2 × 10<jats:sup>−9</jats:sup>/rs11248060; T: OR = 1.35; <jats:italic>p</jats:italic> = 2.0 × 10<jats:sup>−9</jats:sup>), and the human leukocyte antigen (HLA) region (rs3129882; A: OR = 0.83; <jats:italic>p</jats:italic> = 1.2 × 10<jats:sup>−8</jats:sup>), which were previously reported. The Replication Sample confirmed the associations with <jats:italic>SNCA</jats:italic>, <jats:italic>MAPT</jats:italic>, and the HLA region and also with <jats:italic>GBA</jats:italic> (E326K; OR = 1.71; <jats:italic>p</jats:italic> = 5 × 10<jats:sup>−8</jats:sup> Combined Sample) (N370; OR = 3.08; <jats:italic>p</jats:italic> = 7 × 10<jats:sup>−5</jats:sup> Replication sample). A novel PD susceptibility locus, <jats:italic>RIT2</jats:italic>, on chromosome 18 (rs12456492; <jats:italic>p</jats:italic> = 5 × 10<jats:sup>−5</jats:sup> Discovery Sample; <jats:italic>p</jats:italic> = 1.52 × 10<jats:sup>−7</jats:sup> Replication sample; <jats:italic>p</jats:italic> = 2 × 10<jats:sup>−10</jats:sup> Combined Sample) was replicated. Conditional analyses within each of the replicated regions identified distinct SNP associations within <jats:italic>GBA</jats:italic> and <jats:italic>SNCA</jats:italic>, suggesting that there may be multiple risk alleles within these genes.</jats:p></jats:sec><jats:sec><jats:title>Interpretation:</jats:title><jats:p>We identified a novel PD susceptibility locus, <jats:italic>RIT2</jats:italic>, replicated several previously identified loci, and identified more than 1 risk allele within <jats:italic>SNCA</jats:italic> and <jats:italic>GBA</jats:italic>.ANN NEUROL 2012;</jats:p></jats:sec>

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