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Media type:
E-Article
Title:
Necrotizing arteritis and spinal subarachnoid hemorrhage in Sjögren syndrome
Contributor:
Alexander, Elaine L.;
Craft, Carolyn;
Dorsch, Carole;
Moser, Robert L.;
Provost, Thomas T.;
Alexander, Garrett E.
Published:
Wiley, 1982
Published in:
Annals of Neurology, 11 (1982) 6, Seite 632-635
Language:
English
DOI:
10.1002/ana.410110614
ISSN:
0364-5134;
1531-8249
Origination:
Footnote:
Description:
AbstractA 37‐year‐old woman with primary Sjögren syndrome developed mixed cryoglobulinemia and systemic vasculitis. Subarachnoid hemorrhage occurred as a result of necrotizing anterior spinal arteritis. Although rarely seen in mixed cryoglobulinemia, central nervous system complications have recently been documented in Sjögren syndrome. The patient's serum contained antibodies to the Ro(SSA) cytoplasmic antigen, and these antibodies were concentrated in the cryoglobulin fraction. Anti‐Ro(SSA) antibodies are associated with the occurrence of vasculitis in patients with Sjögren syndrome, which suggests that the spinal arteritis and subarachnoid hemorrhage in this patient may have been directly related to the underlying connective tissue disorder.