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Yahaya, Nasiru P.; Appleby, Kate M.; Teh, Magdalene; Wagner, Conrad; Troschke, Erik; Bray, Joshua T. W.; Duckett, Simon B.; Hammarback, L. Anders; Ward, Jonathan S.; Milani, Jessica; Pridmore, Natalie E.; Whitwood, Adrian C.; Lynam, Jason M.; Fairlamb, Ian J. S.

Manganese(I)‐Catalyzed C−H Activation: The Key Role of a 7‐Membered Manganacycle in H‐Transfer and Reductive Elimination

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  • Media type: E-Article
  • Title: Manganese(I)‐Catalyzed C−H Activation: The Key Role of a 7‐Membered Manganacycle in H‐Transfer and Reductive Elimination
  • Contributor: Yahaya, Nasiru P.; Appleby, Kate M.; Teh, Magdalene; Wagner, Conrad; Troschke, Erik; Bray, Joshua T. W.; Duckett, Simon B.; Hammarback, L. Anders; Ward, Jonathan S.; Milani, Jessica; Pridmore, Natalie E.; Whitwood, Adrian C.; Lynam, Jason M.; Fairlamb, Ian J. S.
  • imprint: Wiley, 2016
  • Published in: Angewandte Chemie
  • Language: English
  • DOI: 10.1002/ange.201606236
  • ISSN: 0044-8249; 1521-3757
  • Keywords: General Medicine
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>Manganese‐catalyzed C−H bond activation chemistry is emerging as a powerful and complementary method for molecular functionalization. A highly reactive seven‐membered Mn<jats:sup>I</jats:sup> intermediate is detected and characterized that is effective for H‐transfer or reductive elimination to deliver alkenylated or pyridinium products, respectively. The two pathways are determined at Mn<jats:sup>I</jats:sup> by judicious choice of an electron‐deficient 2‐pyrone substrate containing a 2‐pyridyl directing group, which undergoes regioselective C−H bond activation, serving as a valuable system for probing the mechanistic features of Mn C−H bond activation chemistry.</jats:p>