Bolt, Robert R. A.;
Raby‐Buck, Sarah E.;
Ingram, Katharine;
Leitch, Jamie A.;
Browne, Duncan L.
Temperature‐Controlled Mechanochemistry for the Nickel‐Catalyzed Suzuki–Miyaura‐Type Coupling of Aryl Sulfamates via Ball Milling and Twin‐Screw Extrusion.**
You can manage bookmarks using lists, please log in to your user account for this.
Media type:
E-Article
Title:
Temperature‐Controlled Mechanochemistry for the Nickel‐Catalyzed Suzuki–Miyaura‐Type Coupling of Aryl Sulfamates via Ball Milling and Twin‐Screw Extrusion.**
Contributor:
Bolt, Robert R. A.;
Raby‐Buck, Sarah E.;
Ingram, Katharine;
Leitch, Jamie A.;
Browne, Duncan L.
Published:
Wiley, 2022
Published in:
Angewandte Chemie, 134 (2022) 44
Language:
English
DOI:
10.1002/ange.202210508
ISSN:
0044-8249;
1521-3757
Origination:
Footnote:
Description:
AbstractThe use of temperature‐controlled mechanochemistry to enable the mechanochemical nickel‐catalyzed Suzuki–Miyaura coupling is herein described. Transitioning from a capricious room‐temperature protocol, through to a heated, PID‐controlled programmable jar heater manifold was required to deliver an efficient method for the coupling of aryl sulfamates (derived from ubiquitous phenols) and aryl boronic acid species. Furthermore, this process is conducted using a base‐metal nickel catalyst, in the absence of bulk solvent, and in the absence of air/moisture sensitive reaction set‐ups. This methodology is showcased through translation to large‐scale twin‐screw extrusion methodology enabling 200‐fold scale increase, producing decagram quantities of C−C coupled material.