> Details

Stephens, Amberley D.; Kölbel, Johanna; Moons, Rani; Chung, Chyi Wei; Ruggiero, Michael T.; Mahmoudi, Najet; Shmool, Talia A.; McCoy, Thomas M.; Nietlispach, Daniel; Routh, Alexander F.; Sobott, Frank; Zeitler, J. Axel; Kaminski Schierle, Gabriele S.

Decreased Water Mobility Contributes To Increased α‐Synuclein Aggregation**

Reference
management

Bookmarks

Remove from
bookmarks

Share this on Whatsapp

Close

Bookmarks



You can manage bookmarks using lists, please log in to your user account for this.
  • Media type: E-Article
  • Title: Decreased Water Mobility Contributes To Increased α‐Synuclein Aggregation**
  • Contributor: Stephens, Amberley D.; Kölbel, Johanna; Moons, Rani; Chung, Chyi Wei; Ruggiero, Michael T.; Mahmoudi, Najet; Shmool, Talia A.; McCoy, Thomas M.; Nietlispach, Daniel; Routh, Alexander F.; Sobott, Frank; Zeitler, J. Axel; Kaminski Schierle, Gabriele S.
  • Published: Wiley, 2023
  • Published in: Angewandte Chemie, 135 (2023) 7
  • Language: English
  • DOI: 10.1002/ange.202212063
  • ISSN: 1521-3757; 0044-8249
  • Origination:
  • Footnote:
  • Description: AbstractThe solvation shell is essential for the folding and function of proteins, but how it contributes to protein misfolding and aggregation has still to be elucidated. We show that the mobility of solvation shell H2O molecules influences the aggregation rate of the amyloid protein α‐synuclein (αSyn), a protein associated with Parkinson's disease. When the mobility of H2O within the solvation shell is reduced by the presence of NaCl, αSyn aggregation rate increases. Conversely, in the presence CsI the mobility of the solvation shell is increased and αSyn aggregation is reduced. Changing the solvent from H2O to D2O leads to increased aggregation rates, indicating a solvent driven effect. We show the increased aggregation rate is not directly due to a change in the structural conformations of αSyn, it is also influenced by a reduction in both the H2O mobility and αSyn mobility. We propose that reduced mobility of αSyn contributes to increased aggregation by promoting intermolecular interactions.