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Media type:
E-Article
Title:
Transition‐Metal‐Catalyzed Utilization of Methanol as a C1 Source in Organic Synthesis
Contributor:
Natte, Kishore;
Neumann, Helfried;
Beller, Matthias;
Jagadeesh, Rajenahally V.
imprint:
Wiley, 2017
Published in:Angewandte Chemie International Edition
Language:
English
DOI:
10.1002/anie.201612520
ISSN:
1433-7851;
1521-3773
Origination:
Footnote:
Description:
<jats:title>Abstract</jats:title><jats:p>Methanol is used as a common solvent, cost‐effective reagent, and sustainable feedstock for value‐added chemicals, pharmaceuticals, and materials. Among the various applications, the utilization of methanol as a C<jats:sub>1</jats:sub> source for the formation of carbon–carbon, carbon–nitrogen, and carbon–oxygen bonds continues to be important in organic synthesis and drug discovery. In particular, the synthesis of C‐, N‐, and O‐methylated products is of central interest because these motifs are found in a large number of natural products as well as fine and bulk chemicals. In this Minireview, we summarize the utilization of methanol as a C<jats:sub>1</jats:sub> source in methylation, methoxylation, formylation, methoxycarbonylation, and oxidative methyl ester formation reactions.</jats:p>