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Media type:
E-Article
Title:
Highly Productive Oxidative Biocatalysis in Continuous Flow by Enhancing the Aqueous Equilibrium Solubility of Oxygen
Contributor:
Chapman, Michael R.;
Cosgrove, Sebastian C.;
Turner, Nicholas J.;
Kapur, Nikil;
Blacker, A. John
Published:
Wiley, 2018
Published in:
Angewandte Chemie International Edition, 57 (2018) 33, Seite 10535-10539
Language:
English
DOI:
10.1002/anie.201803675
ISSN:
1433-7851;
1521-3773
Origination:
Footnote:
Description:
AbstractWe report a simple, mild, and synthetically clean approach to accelerate the rate of enzymatic oxidation reactions by a factor of up to 100 when compared to conventional batch gas/liquid systems. Biocatalytic decomposition of H2O2 is used to produce a soluble source of O2 directly in reaction media, thereby enabling the concentration of aqueous O2 to be increased beyond equilibrium solubility under safe and practical conditions. To best exploit this method, a novel flow reactor was developed to maximize productivity (g product L−1 h−1). This scalable benchtop method provides a distinct advantage over conventional bio‐oxidation in that no pressurized gas or specialist equipment is employed. The method is general across different oxidase enzymes and compatible with a variety of functional groups. These results culminate in record space‐time yields for bio‐oxidation.