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Media type:
E-Article
Title:
Reusable Nickel Nanoparticles‐Catalyzed Reductive Amination for Selective Synthesis of Primary Amines
Contributor:
Murugesan, Kathiravan;
Beller, Matthias;
Jagadeesh, Rajenahally V.
imprint:
Wiley, 2019
Published in:Angewandte Chemie International Edition
Language:
English
DOI:
10.1002/anie.201812100
ISSN:
1521-3773;
1433-7851
Origination:
Footnote:
Description:
<jats:title>Abstract</jats:title><jats:p>The preparation of nickel nanoparticles as efficient reductive amination catalysts by pyrolysis of in situ generated Ni‐tartaric acid complex on silica is presented. The resulting stable and reusable Ni‐nanocatalyst enables the synthesis of functionalized and structurally diverse primary benzylic, heterocyclic and aliphatic amines starting from inexpensive and readily available carbonyl compounds and ammonia in presence of molecular hydrogen. Applying this Ni‐based amination protocol, ‐NH<jats:sub>2</jats:sub> moiety can be introduced in structurally complex compounds, for example, steroid derivatives and pharmaceuticals.</jats:p>