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Media type:
E-Article
Title:
pH‐Responsive Calcium Ions and Crocetin Releasing Hydrogel for Accelerating Skin Wound Healing
Contributor:
Wang, Li;
Ma, Xuemei;
Pan, Yanan;
Ye, Haoxiang;
Liu, Zike;
Kuang, Zaoyuan;
Zhao, Zhongxiang;
Liu, Aijun;
Ji, Yuxing
Published:
Wiley, 2024
Published in:
Chemistry – An Asian Journal (2024)
Language:
English
DOI:
10.1002/asia.202400198
ISSN:
1861-4728;
1861-471X
Origination:
Footnote:
Description:
<jats:title>Abstract</jats:title><jats:p>The ideal and highly anticipated dressing for skin wounds should provide a moist environment, possess antibacterial properties, and ensure sustained drug release. In the present work, a hyaluronic acid‐based hydrogel was formed by cross‐linking crocetin and CaCO<jats:sub>3</jats:sub>@polyelectrolyte materials (CaCO<jats:sub>3</jats:sub>@PEM) microspheres with HA hydrogels via hydrogen bond and amido bonding (CaCO<jats:sub>3</jats:sub>@PEM@Cro@HA hydrogel, CPC@HA hydrogel). Moreover, the CPC@HA hydrogel had the capability of sustained, controlled release of calcium ions and crocetin via pH‐sensitive and accelerated skin wound healing. The experiment results showed that the CPC@HA hydrogel exhibited porous network structures, stable physical properties, and had antibacterial properties and biocompatibility <jats:italic>in vitro</jats:italic>. In addition, the CPC@HA hydrogel covering on the skin wound could reduce inflammation and promote wound healing. The high expression of angiogenic cytokines (CD31) and epidermal terminal differentiation markers (Loricrin) of wound healing tissue suggested the CPC@HA hydrogel also had the function of promoting the remodeling of regenerated skin. Overall, CPC@HA hydrogel has promising potential for clinical applications in accelerating skin wound repair.</jats:p>