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Spaltro, Suree M.; Foster, Natalie

Synthesis and characterization of conjugates of poly(α‐amino acids) and manganese (III) protoporphyrin IX as relaxation enhancement agents for MRI

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  • Media type: E-Article
  • Title: Synthesis and characterization of conjugates of poly(α‐amino acids) and manganese (III) protoporphyrin IX as relaxation enhancement agents for MRI
  • Contributor: Spaltro, Suree M.; Foster, Natalie
  • Published: Wiley, 1990
  • Published in: Journal of Applied Polymer Science, 41 (1990) 5-6, Seite 1235-1249
  • Language: English
  • DOI: 10.1002/app.1990.070410532
  • ISSN: 0021-8995; 1097-4628
  • Keywords: Materials Chemistry ; Polymers and Plastics ; Surfaces, Coatings and Films ; General Chemistry
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>Polymers are finding increasing use in medicine, and conjugates of paramagnetic species and polymers are now being studied as relaxation enhancement agents to improve contrast in magnetic resonance imaging. To assess the potential of such agents, the enhancement of proton relaxation by paramagnetic species bound to macromolecules has been observed for four conjugates of amino acid polymers and manganese (III) protoporphyrin IX. The conjugates all differ in their abilities to enhance the relaxation of water protons in solution; values of relaxation rates range from 3.2 to 9.1 s<jats:sup>−1</jats:sup> mM<jats:sup>−1</jats:sup>. The rotational correlation times and volumes of the kinetic units within the macromolecules have been determined by fluorescence depolarization in an effort to understand the range of relaxation rates observed for the conjugates. The metalloporphyrins bound to the polymers all have very similar dynamic characteristics.</jats:p>