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Media type:
E-Article
Title:
Inhibition of mixed leukocyte culture responses by serum and γ‐globulin fractions from certain patients with connective tissue disorders
Contributor:
Williams, Ralph C.;
Lies, Richard B.;
Messner, Ronald P.
Published:
Wiley, 1973
Published in:
Arthritis & Rheumatism, 16 (1973) 5, Seite 597-605
Language:
English
DOI:
10.1002/art.1780160504
ISSN:
1529-0131;
0004-3591
Origination:
Footnote:
Description:
AbstractSera and IgG fractions from normal subjects as well as patients with rheumatoid arthritis and systemic lupus erythematosus were added to mixed leukocyte reactions (MLC) in an attempt to study the effects on cell‐to‐cell interactions in such systems. Seven and seven‐tenths percent of 52 RA sera and 26% of 27 SLE sera showed suppression of MLC reactivity. MLC suppression appeared to be localized to IgG serum fractions separated by DEAE chromatography. This suppressive effect showed a strong correlation with presence of lymphocytotoxic antibody in individual sera.