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Media type:
E-Article
Title:
Cellular and molecular diversity in skeletal muscle development: News from in vitro and in vivo
Contributor:
Miller, Jeffrey Boone;
Everitt, Elizabeth A.;
Smith, Timothy H.;
Block, Nancy E.;
Dominov, Janice A.
Published:
Wiley, 1993
Published in:
BioEssays, 15 (1993) 3, Seite 191-196
Language:
English
DOI:
10.1002/bies.950150308
ISSN:
0265-9247;
1521-1878
Origination:
Footnote:
Description:
AbstractSkeletal muscle formation is studied in vitro with myogenic cell lines and primary muscle cell cultures, and in vivo with embryos of several species. We review several of the notable advances obtained from studies of cultured cells, including the recognition of myoblast diversity, isolation of the MyoD family of muscle regulatory factors, and identification of promoter elements required for muscle‐specific gene expression. These studies have led to the ideas that myoblast diversity underlies the formation of the multiple types of fast and slow muscle fibers, and that myogenesis is controlled by a combination of ubiquitous and muscle‐specific transcriptional regulators that may be different for each gene. We further review some unexpected results that have been obtained when ideas from work in culture have been tested in developing animals. The studies in vivo point to additional molecular and cellular mechanisms that regulate muscle formation in the animal.