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Media type:
E-Article
Title:
Effect of antibiotics in fibrin sealant on healing colonic anastomoses in the rat
Contributor:
van der Ham, A C;
Kort, W J;
Weijma, I M;
van den Ingh, H F G M;
Jeekel, H
Published:
Oxford University Press (OUP), 1992
Published in:
Journal of British Surgery, 79 (1992) 6, Seite 525-528
Language:
English
DOI:
10.1002/bjs.1800790617
ISSN:
1365-2168;
0007-1323
Origination:
Footnote:
Description:
Abstract In 90 rats a colonic anastornosis was constructed with 12 interrupted 7/0 polypropylene sutures. Group 1 (n = 30) served as a control group. In group 2 (n = 30) the anastomosis was sealed with, fibrin adhesive and in group 3 (n = 30) a mixture of fibrin, clindamycin and cefotaxime was used. On days 2, 4 and 7, ten animals in each group were killed. Adhesion formation was significantly increased in groups 2 and 3 compared with the control group. On day 2 the anastomosis was significantly stronger after sealing with antibiotic–fibrin mixture. On day 4 the bursting pressure in group 2 was significantly lower than in groups 1 and 3. At the same time the concentration of hydroxyproline was significantly reduced in group 2, but not in group 3. The addition of antibiotics prevents the negative effect of fibrin adhesive on the healing colonic anastomosis and contributes to a stronger anastomosis on day 2 after operation.