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Tarantini, Giuseppe; Mojoli, Marco; Masiero, Giulia; Cortese, Bernardo; Loi, Bruno; Varricchio, Attilio; Gabrielli, Gabriele; Durante, Alessandro; Pasquetto, Giampaolo; Calabrò, Paolo; Gistri, Roberto; Tumminello, Gabriele; Misuraca, Leonardo; Pisano, Francesco; Ielasi, Alfonso; Mazzarotto, Pietro; Coscarelli, Sebastian; Lucci, Valerio; Moretti, Luciano; Nicolino, Annamaria; Colombo, Alessandro; Olivari, Zoran; Fineschi, Massimo; Piraino, Davide; [...]

Clinical outcomes of overlapping versus non‐overlapping everolimus‐eluting absorb bioresorbable vascular scaffolds: An analysis from the multicentre prospective RAI registry (ClinicalTrials.gov identifier: NCT02298413)

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  • Media type: E-Article
  • Title: Clinical outcomes of overlapping versus non‐overlapping everolimus‐eluting absorb bioresorbable vascular scaffolds: An analysis from the multicentre prospective RAI registry (ClinicalTrials.gov identifier: NCT02298413)
  • Contributor: Tarantini, Giuseppe; Mojoli, Marco; Masiero, Giulia; Cortese, Bernardo; Loi, Bruno; Varricchio, Attilio; Gabrielli, Gabriele; Durante, Alessandro; Pasquetto, Giampaolo; Calabrò, Paolo; Gistri, Roberto; Tumminello, Gabriele; Misuraca, Leonardo; Pisano, Francesco; Ielasi, Alfonso; Mazzarotto, Pietro; Coscarelli, Sebastian; Lucci, Valerio; Moretti, Luciano; Nicolino, Annamaria; Colombo, Alessandro; Olivari, Zoran; Fineschi, Massimo; Piraino, Davide; [...]
  • imprint: Wiley, 2018
  • Published in: Catheterization and Cardiovascular Interventions
  • Language: English
  • DOI: 10.1002/ccd.27095
  • ISSN: 1522-1946; 1522-726X
  • Keywords: Cardiology and Cardiovascular Medicine ; Radiology, Nuclear Medicine and imaging ; General Medicine
  • Origination:
  • Footnote:
  • Description: <jats:sec><jats:title>Objectives</jats:title><jats:p>To compare clinical outcomes of patients treated with overlapping versus non‐overlapping Absorb BVS. <jats:bold>Background</jats:bold>: Limited data are available on the clinical impact of stent overlap with the Absorb BVS bioresorbable stent. <jats:bold>Methods</jats:bold>: We compared outcomes of patients receiving overlapping or non‐overlapping Absorb BVS in the multicenter prospective RAI Registry. <jats:bold>Results</jats:bold>: Out of 1,505 consecutive patients treated with Absorb BVS, 1,384 were eligible for this analysis. Of these, 377 (27%) were in the overlap group, and 1,007 (73%) in the non‐overlap group. The most frequent overlap configuration was the marker‐to‐marker type (48%), followed by marker‐over‐marker (46%) and marker‐inside‐marker (6%) types. Patients of the overlap group had higher prevalence of multivessel disease and higher SYNTAX score, and required more frequently the use of intravascular imaging. At a median follow‐up of 368 days, no difference was observed between overlap and non‐overlap groups in terms of a device‐related composite endpoint (cardiac death, TV‐MI, ID‐TLR) (5.8% vs. 4.1%, <jats:italic>P</jats:italic> = 0.20) or of a patient‐related composite endpoint (any death, any MI, any revascularization) (15.4% vs. 12.5%, <jats:italic>P</jats:italic> = 0.18). Cardiac death (1.0% vs. 1.3%, <jats:italic>P</jats:italic> = 0.54), MI (4.5% vs. 3.6%, <jats:italic>P</jats:italic> = 0.51), TVR (4.5% vs. 3.6%, <jats:italic>P</jats:italic> = 0.51) and stent thrombosis (1.1 vs. 1.5%, <jats:italic>P</jats:italic> = 1.00) were also comparable between groups. When assessing outcomes of the overlap population according to overlap configurations used, no difference was observed in terms of the device‐ or patient‐related composite endpoints. <jats:bold>Conclusions</jats:bold>: Outcomes of patients with or without overlapping BVS were comparable at mid‐term follow‐up despite higher angiographic complexity of the overlap subset. © 2017 Wiley Periodicals, Inc.</jats:p></jats:sec>