Description:
<jats:title>Abstract</jats:title><jats:p>The novel formate oxidase from <jats:italic>Aspergillus oryzae</jats:italic> (<jats:italic>Ao</jats:italic>FOx) is a useful catalyst to promote H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>‐dependent oxyfunctionalisation reactions. In this contribution we exploit the substrate promiscuity of <jats:italic>Ao</jats:italic>FOx to fully oxidise methanol and formaldehyde to CO<jats:sub>2</jats:sub> and drive peroxygenase‐catalysed stereoselective oxyfunctionalisation reactions. The highly atom efficient H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> generation system also enabled high catalytic turnover of the peroxygenase production enzyme.</jats:p>