Published in:
Chemistry & Biodiversity, 4 (2007) 5, Seite 932-939
Language:
English
DOI:
10.1002/cbdv.200790082
ISSN:
1612-1872;
1612-1880
Origination:
Footnote:
Description:
AbstractFive new derivatives of the pentacyclic triterpenoid lantadene A (=22β‐angeloyloxy‐3‐oxoolean‐12‐en‐28‐oic acid; 1) from the leaves of Lantana camara L. were synthesized, characterized, and screened for their cytotoxicities against four human cancer cell lines. The three most‐potent compounds, i.e., 1, 4, and 6, with IC50 values in the range of ca. 20–29 μM, were further studied for their in vivo tumor‐inhibitory potential upon oral administration in two‐stage squamous cell carcinogenesis, using female Swiss albino mice, papilloma being induced by 7,12‐dimethylbenz[a]anthracene (DMBA), and promoted by 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA). The results are discussed in terms of structure–activity relationship.