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Chlebek, Jakub; Novák, Zdeněk; Kassemová, Dominika; Šafratová, Marcela; Kostelník, Jan; Malý, Lukáš; Ločárek, Miroslav; Opletal, Lubomír; Hošt'álková, Anna; Hrabinová, Martina; Kuneš, Jiří; Novotná, Pavlína; Urbanová, Marie; Nováková, Lucie; Macáková, Kateřina; Hulcová, Daniela; Solich, Petr; Pérez Martín, Concepción; Jun, Daniel; Cahlíková, Lucie

Isoquinoline Alkaloids from Fumaria officinalis L. and Their Biological Activities Related to Alzheimer's Disease

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  • Media type: E-Article
  • Title: Isoquinoline Alkaloids from Fumaria officinalis L. and Their Biological Activities Related to Alzheimer's Disease
  • Contributor: Chlebek, Jakub; Novák, Zdeněk; Kassemová, Dominika; Šafratová, Marcela; Kostelník, Jan; Malý, Lukáš; Ločárek, Miroslav; Opletal, Lubomír; Hošt'álková, Anna; Hrabinová, Martina; Kuneš, Jiří; Novotná, Pavlína; Urbanová, Marie; Nováková, Lucie; Macáková, Kateřina; Hulcová, Daniela; Solich, Petr; Pérez Martín, Concepción; Jun, Daniel; Cahlíková, Lucie
  • imprint: Wiley, 2016
  • Published in: Chemistry & Biodiversity
  • Language: English
  • DOI: 10.1002/cbdv.201500033
  • ISSN: 1612-1872; 1612-1880
  • Keywords: Molecular Biology ; Molecular Medicine ; General Chemistry ; Biochemistry ; General Medicine ; Bioengineering
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>Two new isoquinoline alkaloids, named fumaranine (<jats:bold>2</jats:bold>) and fumarostrejdine (<jats:bold>10</jats:bold>), along with 18 known alkaloids were isolated from aerial parts of <jats:italic>Fumaria officinalis.</jats:italic> The structures of the isolated compounds were elucidated on the basis of spectroscopic analyses and by comparison with literature data. The absolute configuration of the new compound <jats:bold>2</jats:bold> was determined by comparing its circular dichroism spectra with those of known analogs. Compounds isolated in sufficient amounts were evaluated for their acetylcholinesterase, butyrylcholinesterase, prolyl oligopeptidase (POP), and glycogen synthase kinase‐3<jats:italic>β</jats:italic> inhibitory activities. Parfumidine (<jats:bold>8</jats:bold>) and sinactine (<jats:bold>15</jats:bold>) exhibited potent POP inhibition activities (<jats:italic>IC</jats:italic><jats:sub>50</jats:sub> 99±5 and 53±2 μ<jats:sc>M</jats:sc>, resp.).</jats:p>