Description:
AbstractLeaves of Combretum quadrangulare Kurz showed potent α‐glucosidase inhibition. Two new cycloartane‐type triterpenes, combretic acids D and E were isolated from the bioactive fraction. The chemical structures were determined using NMR and MS methods. Combretic acid D represents for the first cycloartane having a dihydrofuran ring in the side chain. Combretic acids D and E showed significant α‐glucosidase inhibition, with IC50 values of 13.9 and 30.7 μM, respectively. Combretic acid D was determined to be a non‐competitive type in the kinetic study. The docking study in combination with dynamic simulations of this compound provided the molecular understanding of α‐glucosidase inhibition.