Published in:
Chemistry – A European Journal, 21 (2015) 42, Seite 14969-14974
Language:
English
DOI:
10.1002/chem.201500925
ISSN:
0947-6539;
1521-3765
Origination:
Footnote:
Description:
AbstractThe driving forces triggering the formation of co‐crystals under milling conditions were investigated by using a set of multicomponent competitive milling reactions. In these reactions, different active pharmaceutical ingredients were ground together with a further compound acting as coformer. The study was based on new co‐crystals including the coformer anthranilic acid. The results of the competitive milling reactions indicate that the formation of co‐crystals driven by intermolecular recognition are influenced and inhibited by kinetic aspects including the formation of intermediates and the stability of the reactants.