Description:
<jats:title>Abstract</jats:title><jats:p>Herein a new <jats:sup>11</jats:sup>C radiolabelling strategy for the fast and efficient synthesis of thioureas and related derivatives using the novel synthon, <jats:sup>11</jats:sup>CS<jats:sub>2</jats:sub>, is reported. This approach has enabled the facile labelling of a potent progesterone receptor (PR) agonist, [<jats:sup>11</jats:sup>C]Tanaproget, by the intramolecular reaction of the acyclic aminohydroxyl precursor with <jats:sup>11</jats:sup>CS<jats:sub>2</jats:sub>, which has potential applications as a positron emission tomography radioligand for cancer imaging.</jats:p>