Description:
<jats:title>Abstract</jats:title><jats:p>A hydrogen bond of the type C−H⋅⋅⋅X (X=O or N) is known to influence the structure and function of chemical and biological systems in solution. C−H⋅⋅⋅O hydrogen bonding in solution has been extensively studied, both experimentally and computationally, whereas the equivalent thermodynamic parameters have not been enumerated experimentally for C−H⋅⋅⋅N hydrogen bonds. This is, in part, due to the lack of systems that exhibit persistent C−H⋅⋅⋅N hydrogen bonds in solution. Herein, a class of molecule based on a biologically active norharman motif that exhibits unsupported intermolecular C−H⋅⋅⋅N hydrogen bonds in solution has been described. A pairwise interaction leads to dimerisation to give bond strengths of about 7 kJ mol<jats:sup>−1</jats:sup> per hydrogen bond, which is similar to chemically and biologically relevant C−H⋅⋅⋅O hydrogen bonding. The experimental data is supported by computational work, which provides additional insight into the hydrogen bonding by consideration of electrostatic and orbital interactions and allowed a comparison between calculated and extrapolated NMR chemical shifts.</jats:p>