Published in:
Chemistry – A European Journal, 24 (2018) 41, Seite 10397-10402
Language:
English
DOI:
10.1002/chem.201800600
ISSN:
0947-6539;
1521-3765
Origination:
Footnote:
Description:
AbstractMultinuclear complexes or clusters are rarely investigated in medicinal inorganic chemistry although they represent structural intermediates between molecules and nanomaterials. We present in this report two strategies towards 99mTc‐containing clusters. In a pre‐assembly approach, the preformed but incomplete cluster fragment [Re3(μ2‐OH)3(μ3‐OH)(CO)9]− reacts with [99mTc(CO)3]+ to the highly stable [99mTcRe3(μ3‐OH)4(CO)12] cube. The same structure self‐assembles when reacting the mononuclear Re and 99mTc precursors in one pot. Integrating the coordinating OH groups from Schiff bases in this concept leads straight to dinuclear, mixed‐metal complexes of the type [99mTcRe(μ2‐O^N‐R1)2(CO)6] in quantitative yields. Both strategies are unprecedented and open a future path towards clusters, incorporating a 99mTc radiolabel while being decorated with targeting or cytotoxic moieties.