You can manage bookmarks using lists, please log in to your user account for this.
Media type:
E-Article
Title:
Metal–DNA Coordination‐Driven Self‐Assembly: A Conceptual Methodology to Expand the Repertoire of DNA Nanobiotechnology
Contributor:
Liu, Bei;
Zhang, Jingfang;
Li, Lele
Published:
Wiley, 2019
Published in:
Chemistry – A European Journal, 25 (2019) 59, Seite 13452-13457
Language:
English
DOI:
10.1002/chem.201902501
ISSN:
0947-6539;
1521-3765
Origination:
Footnote:
Description:
AbstractThe past several decades have witnessed a rapid revolution of DNA nanotechnology. DNA nanostructures are mainly synthesized with two approaches, by assembly of purely DNA‐based nanostructures through complementary base pairing or grafting DNA onto nanoparticles (NPs). Despite the progress made, developing simple and universal methods for the synthesis of DNA nanoarchitectures with specific morphologies and functionalities is still a challenge. This article introduces the reader to a new biomimetic methodology that leads to the controlled synthesis of DNA nanoarchitectures based on metal–DNA coordination chemistry and, furthermore, demonstrates the broad biomedical applications of these functional materials. In particular, we highlight the coordination‐driven 1) surface‐functionalization of NPs with DNA molecules and 2) direct self‐assembly of metal–DNA nanostructures. Finally, challenges and opportunities of this approach to develop nanobiotechnology are provided.