Description:
<jats:title>Abstract</jats:title><jats:p>Single‐cell sequencing has scientific impacts on better understanding the immunity. There is a rapid development in single cell‐based databases and analytic tools to provide the potential of clinical and translational discovery. The understanding of single‐cell based immunity needs a strong program and solid evidence of preclinical and clinical validation and evaluation. The current special topic issue on single cell and immunity aimed to provide a strong communication for the progress of single cell‐based studies on immune cell functional diversity in development and disease. The topic has a clear scope on the application of single cell sequencing to better understand immune cell heterogeneities, functions, cell–cell interactions, responses and regulatory roles in systems immunology and diseases.</jats:p>