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de Paula, Francisco Danilo Ferreira; Fernandes, Ana Paula; Carmo, Bianca Bianco do; Vieira, Daniela Cristina Duarte; Dutra, Miriam Santos; Santos, Caleb Guedes Miranda dos; Souza, Maria do Carmo M.; Andrade, Túlio César Alvim; Vago, Annamaria Ravara; Fernandes, Paula Ávila

Molecular detection of Chlamydia trachomatis and HPV infections in cervical samples with normal and abnormal cytopathological findings

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  • Media type: E-Article
  • Title: Molecular detection of Chlamydia trachomatis and HPV infections in cervical samples with normal and abnormal cytopathological findings
  • Contributor: de Paula, Francisco Danilo Ferreira; Fernandes, Ana Paula; Carmo, Bianca Bianco do; Vieira, Daniela Cristina Duarte; Dutra, Miriam Santos; Santos, Caleb Guedes Miranda dos; Souza, Maria do Carmo M.; Andrade, Túlio César Alvim; Vago, Annamaria Ravara; Fernandes, Paula Ávila
  • Published: Wiley, 2007
  • Published in: Diagnostic Cytopathology, 35 (2007) 4, Seite 198-202
  • Language: English
  • DOI: 10.1002/dc.20629
  • ISSN: 8755-1039; 1097-0339
  • Keywords: General Medicine ; Histology ; Pathology and Forensic Medicine
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>It has been suggested that <jats:italic>Chlamydia trachomatis</jats:italic> (CT) and human papillomaviruses (HPV) co‐infection could contribute to development of intraepithelial lesions. In this study, HPV and CT‐DNA were investigated in 250 cervicovaginal samples of patients from Minas Gerais, Brazil. The cytological analysis revealed that 70% of samples (175) were negative, 5.2% (13) presented atypical squamous or glandular cells of undetermined significance (ASCUS/AGUS), 12.4% (31) presented low‐grade squamous intraepithelial lesion (LSIL), 10.8% (27) high‐grade squamous intraepithelial lesion (HSIL), and 1.6% (4) invasive carcinoma. HPV‐DNA and HPV/CT co‐infection was observed in 40% (100/250) and in 5.2% (13/250) of samples, respectively. Among the positive cytological samples, HPV‐DNA was detected in 73.3% and CT‐DNA in 9.33% and in 13%, if only the HPV positive samples were considered. The highest co‐infection rate (15.4%) was observed among ASCUS/AGUS samples. Although a significant association was found for HPV infection and the precursor lesions of cervical cancer, it was not possible to establish a significant association between these lesions and CT or HPV/CT co‐infection. Diagn. Cytopathol. 2007;35:198–202. © 2007 Wiley‐Liss, Inc.</jats:p>