Media type: E-Article Title: The role of phospholipase D in Glut‐4 translocation Contributor: Huang, Ping; Frohman, Michael A. imprint: Wiley, 2003 Published in: Diabetes/Metabolism Research and Reviews Language: English DOI: 10.1002/dmrr.416 ISSN: 1520-7552; 1520-7560 Keywords: Endocrinology ; Endocrinology, Diabetes and Metabolism ; Internal Medicine Origination: Footnote: Description: <jats:title>Abstract</jats:title><jats:p>Insulin‐stimulated Glut‐4 translocation is regulated through a complex pathway. Increasing attention is being paid to the role undertaken in this process by Phospholipase D, a signal transduction‐activated enzyme that generates the lipid second‐messenger phosphatidic acid. Phospholipase D facilitates Glut‐4 translocation at potentially multiple steps in its outward movement. Current investigation is centered on Phospholipase D promotion of Glut‐4‐containing membrane vesicle trafficking and vesicle fusion into the plasma membrane, in part through activation of atypical protein kinase C isoforms. Copyright © 2003 John Wiley & Sons, Ltd.</jats:p>