Media type: E-Article Title: Nrl‐Cre transgenic mouse mediates loxP recombination in developing rod photoreceptors Contributor: Brightman, Diana S.; Razafsky, David; Potter, Chloe; Hodzic, Didier; Chen, Shiming imprint: Wiley, 2016 Published in: genesis Language: English DOI: 10.1002/dvg.22918 ISSN: 1526-954X; 1526-968X Origination: Footnote: Description: <jats:title>Summary</jats:title><jats:p>The developing mouse retina is a tractable model for studying neurogenesis and differentiation. Although transgenic <jats:italic>Cre</jats:italic> mouse lines exist to mediate conditional genetic manipulations in developing mouse retinas, none of them act specifically in early developing rods. For conditional genetic manipulations of developing retinas, a <jats:italic>Nrl‐Cre</jats:italic> mouse line in which the <jats:italic>Nrl</jats:italic> promoter drives expression of <jats:italic>Cre</jats:italic> in rod precursors was created. The results showed that <jats:italic>Nrl‐Cre</jats:italic> expression was specific to the retina where it drives rod‐specific recombination with a temporal pattern similar to endogenous <jats:italic>Nrl</jats:italic> expression during retinal development. This <jats:italic>Nrl‐Cre</jats:italic> transgene does not negatively impact retinal structure and function. Taken together, the data suggested that the <jats:italic>Nrl‐Cre</jats:italic> mouse line was a valuable tool to drive Cre‐mediated recombination specifically in developing rods. genesis 54:129–135, 2016. © 2016 Wiley Periodicals, Inc.</jats:p>