Media type: E-Article Title: Chiral Piperazines as Efficient Catalysts for the Asymmetric Michael Addition of Aldehydes to Nitroalkenes Contributor: Barros, Maria Teresa; Faísca Phillips, Ana Maria Published: Wiley, 2007 Published in: European Journal of Organic Chemistry, 2007 (2007) 1, Seite 178-185 Language: English DOI: 10.1002/ejoc.200600731 ISSN: 1434-193X; 1099-0690 Keywords: Organic Chemistry ; Physical and Theoretical Chemistry Origination: Footnote: Description: <jats:title>Abstract</jats:title><jats:p>Chiral piperazines were used as efficient catalysts in the addition of unmodified aldehydes to nitroalkenes. The nature of the solvent, temperature, and catalyst load were found to influence the outcome of the reaction. The products were obtained in good yields up to 88 %, high diastereoselectivities up to 97:3, and high enantiomeric excesses up to 85 %. Plain piperazine and its monohydrochloride were used efficiently as organocatalysts in the synthesis of racemic γ‐formylnitroalkanes. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)</jats:p>