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Media type:
E-Article
Title:
Selective Late‐Stage Hydrodefluorination of Trifluoromethylarenes: A Facile Access to Difluoromethylarenes
Contributor:
Munoz, Socrates B.;
Ni, Chuanfa;
Zhang, Zhe;
Wang, Fang;
Shao, Nan;
Mathew, Thomas;
Olah, George A.;
Prakash, G. K. Surya
imprint:
Wiley, 2017
Published in:European Journal of Organic Chemistry
Language:
English
DOI:
10.1002/ejoc.201700396
ISSN:
1434-193X;
1099-0690
Origination:
Footnote:
Description:
<jats:p>A selective reductive monodefluorination reaction of trifluoromethyl arenes was developed. Mediated by magnesium metal, various difluoromethylated aromatics were accessed at room temperature in the presence of acetic acid. This protocol shows tolerance to a wide range of functional groups and it was applicable in late‐stage hydrodefluorination of complex pharmaceutical compounds, affording the corresponding CF<jats:sub>2</jats:sub>H analogues and their deuterated (CF<jats:sub>2</jats:sub>D) counterparts.</jats:p>