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Media type:
E-Article
Title:
Metal and Solvent‐Free Synthesis of 2H‐Pyrido[1,2‐a]pyrimidin‐2‐ones Catalyzed by Elemental Sulfur
Contributor:
Pavithra, Thangavel;
Devi, E. Sankari;
Nagarajan, Subbiah;
Sridharan, Vellaisamy;
Maheswari, C. Uma
Published:
Wiley, 2019
Published in:
European Journal of Organic Chemistry, 2019 (2019) 40, Seite 6884-6887
Language:
English
DOI:
10.1002/ejoc.201901356
ISSN:
1434-193X;
1099-0690
Origination:
Footnote:
Description:
The efficiency of elemental sulfur for the synthesis of 2H‐pyrido[1,2‐a]pyrimidin‐2‐ones has been demonstrated. This strategy involves coupling of 2‐aminopyridines and β‐oxo esters under neat condition in the absence of external oxidant. The reaction does not require pre‐functionalization of the substrates, thus making it an alternate approach for the synthesis of 2H‐pyrido[1,2‐a]pyrimidin‐2‐ones. The reaction was tolerant to several substituted 2‐aminopyridines and β‐oxo esters.