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Media type:
E-Article
Title:
A High‐Yielding Synthesis of EIDD‐2801 from Uridine**
Contributor:
Steiner, Alexander;
Znidar, Desiree;
Ötvös, Sándor B.;
Snead, David R.;
Dallinger, Doris;
Kappe, C. Oliver
Published:
Wiley, 2020
Published in:
European Journal of Organic Chemistry, 2020 (2020) 43, Seite 6736-6739
Language:
English
DOI:
10.1002/ejoc.202001340
ISSN:
1434-193X;
1099-0690
Origination:
Footnote:
Description:
A simple reordering of the reaction sequence allowed the improved synthesis of EIDD‐2801, an antiviral drug with promising activity against the SARS‐CoV‐2 virus, starting from uridine. Compared to the original route, the yield was enhanced from 17 % to 61 %, and fewer isolation/purification steps were needed. In addition, a continuous flow procedure for the final acetonide deprotection was developed, which proved to be favorable toward selectivity and reproducibility.