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Media type:
E-Article
Title:
Solid tumors “melt” from the inside after successful CD8 T cell attack
Contributor:
Blohm, Ulrike;
Potthoff, Dan;
van der Kogel, Albert J.;
Pircher, Hanspeter
Published:
Wiley, 2006
Published in:
European Journal of Immunology, 36 (2006) 2, Seite 468-477
Language:
English
DOI:
10.1002/eji.200526175
ISSN:
0014-2980;
1521-4141
Origination:
Footnote:
Description:
AbstractAdoptive transfer of tumor‐specific T cells represents a promising approach for cancer immunotherapy. Here, we visualized the anti‐tumor response of CD8 T cells from P14 TCR‐transgenic mice specific for the model antigen GP33 by immunohistology. P14 T cells, adoptively transferred into tumor‐bearing hosts, induced regression of established 3LL‐A9GP33 and MCA102GP33 tumors that express GP33 as a tumor‐associated model antigen. Strikingly, the visible effects of P14 T cell attack, such as the destruction of the tumor vasculature and accumulation of granulocytes, were predominantly detected inside the tumor mass. In regressing tumors, P14 T cells were found in the intact rim zone but not in central areas that were infiltrated with granulocytes and lacked CD31+ endothelial cells. The rim of P14 T cell‐treated tumors showed an increase in vascular density and decrease in hypoxia compared to untreated tumors. Hypoxic areas of tumors are known to exhibit decreased sensitivity to radiation therapy or chemotherapy. Thus, our data also imply that adoptive transfer of tumor‐specific CD8 T cells might synergize with radiation therapy or chemotherapy in the elimination of solid tumors in vivo.