Fabrication of a Label‐free Femtomolar Electrochemical Mercury Ion Biosensor Based on Oligonucleotide Receptor Layers Hybridized with Multi‐walled Carbon Nanotubes
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Media type:
E-Article
Title:
Fabrication of a Label‐free Femtomolar Electrochemical Mercury Ion Biosensor Based on Oligonucleotide Receptor Layers Hybridized with Multi‐walled Carbon Nanotubes
Contributor:
Pal, Chittatosh;
Majumder, Subrata
Published:
Wiley, 2022
Published in:
Electroanalysis, 34 (2022) 11, Seite 1673-1681
Language:
English
DOI:
10.1002/elan.202100615
ISSN:
1040-0397;
1521-4109
Origination:
Footnote:
Description:
AbstractThe feasibility of designing a highly selective and sensitive label‐free cost‐effective biosensor to determine Hg2+ions using gold electrodes functionalized with short‐chain, thymine‐rich, ss‐DNA oligonucleotides wrapped MWNTs is examined. The potassium ferricyanide was used as a redox marker for analytical signal generation. Biosensor response was based on the difference in the electrochemical signal before and after subjecting it to a sample containing Hg2+ions. The lowest detection limit of 1 femtomolar (fM) of mercury ions was observed in the aqueous medium, together with good selectivity against common metal cations. The method developed was successfully applied for the determination of Hg2+ions in environmental waste water samples.