Media type: E-Article Title: Mammalian glucocorticoid metabolites act as androgenic endocrine disruptors in the medaka (Oryzias latipes) Contributor: Grillitsch, Britta; Altmann, Dominik; Schabuss, Michael; Zornig, Horst; Sommerfeld‐Stur, Irene; Möstl, Erich Published: Wiley, 2010 Published in: Environmental Toxicology and Chemistry, 29 (2010) 7, Seite 1613-1620 Language: English DOI: 10.1002/etc.176 ISSN: 0730-7268; 1552-8618 Keywords: Health, Toxicology and Mutagenesis ; Environmental Chemistry Origination: Footnote: Description: AbstractGlucocorticoid metabolites enter the aquatic environment via mammalian excrements. Molecular structures of their C19O3 metabolites strongly resemble the major fish androgen 11‐ketotestosterone. Therefore, we tested the hypothesis that the cortisol metabolite 5α‐androstan‐3,11,17‐trione acts similarly to 11‐ketotestosterone by employing a fish screening assay for endocrine‐active substances. After 21 d, both 11‐oxygenated compounds had masculinized sex characteristics of the anal fin in female medaka in a dose‐dependent manner. Environ. Toxicol. Chem. 2010;29:1613–1620. © 2010 SETAC