Media type: E-Article Title: Age‐related morphology trends of cortical sulci Contributor: Kochunov, Peter; Mangin, Jean‐François; Coyle, Thomas; Lancaster, Jack; Thompson, Paul; Rivière, Dennis; Cointepas, Yann; Régis, Jean; Schlosser, Anita; Royall, Don R.; Zilles, Karl; Mazziotta, John; Toga, Arthur; Fox, Peter T. imprint: Wiley, 2005 Published in: Human Brain Mapping Language: English DOI: 10.1002/hbm.20198 ISSN: 1065-9471; 1097-0193 Origination: Footnote: Description: <jats:title>Abstract</jats:title><jats:p>The age‐related trends of the width and the depth of major cortical sulci were studied in normal adults. Ninety healthy subjects (47 males, 43 females) age 20–82 years were evaluated. Measurements of average sulcal width and depth in 14 prominent sulcal structures per hemisphere were performed with high‐resolution anatomical MRI. The average sulcal width increased at a rate of about 0.7 mm/decade, while the average sulcal depth decreased at a rate of about 0.4 mm/decade. Sulcal age‐related trends were found to be highly influenced by gender in the superior temporal, collateral, and cingulate sulci (<jats:italic>P</jats:italic> < 0.05), with males showing more pronounced age‐related change in sulcal width than females. Sulcal structures located in multimodal cortical areas showed more profound age‐related changes than sulcal structures in unimodal cortical areas (<jats:italic>P</jats:italic> < 0.05). Hum Brain Mapp, 2005. © 2005 Wiley‐Liss, Inc.</jats:p> Access State: Open Access