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Schirmeister, Helga; Pfleiderer, Wolfgang

Nucleotides Part XL. Synthesis and Characterization of Modified 2′–5′ Adenylate Trimers–Potential Antiviral Agents

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  • Media type: E-Article
  • Title: Nucleotides Part XL. Synthesis and Characterization of Modified 2′–5′ Adenylate Trimers–Potential Antiviral Agents
  • Contributor: Schirmeister, Helga; Pfleiderer, Wolfgang
  • Published: Wiley, 1994
  • Published in: Helvetica Chimica Acta, 77 (1994) 1, Seite 10-22
  • Language: English
  • DOI: 10.1002/hlca.19940770104
  • ISSN: 1522-2675; 0018-019X
  • Keywords: Inorganic Chemistry ; Organic Chemistry ; Physical and Theoretical Chemistry ; Drug Discovery ; Biochemistry ; Catalysis
  • Origination:
  • Footnote:
  • Description: Abstract2′–5′ Adenylate trimers 41–44 carrying the (tert‐butyl)dimethylsilyl (tbds) group at the 3′‐OH position of various sugar moieties were synthesized via the phosphoramidite method. The use of the (tert‐butyloxy)carbonyl (boc) and 2‐(4‐nitrophenyl)ethylsulfonyl (npes) groups for 2′‐OH protection in neighbourhood to the 3′‐O‐tbds residue was compared during the synthesis of the target trimers. For other functional positions, the use of the 2‐(4‐nitrophenyl)ethyl (npe) and 2‐(4‐nitrophenyl)ethoxycarbonyl (npeoc) blocking groups were favoured.