Description:
<jats:p>In order to limit the side effects associated with antitumor drugs such as doxorubicin, nanosized drug‐delivery systems capable of selectively delivering and releasing the drug in the diseased tissue are required. We describe nanoparticles (<jats:styled-content style="fixed-case">NP</jats:styled-content>s), self‐assembled from a reduction responsive amphiphilic peptide, capable of entrapping high amounts of a redox active anticancer drug candidate and releasing it in presence of a reducing agent. This system shows a high entrapment efficiency with up to 15 mg drug per gram of peptide (5.8 mol‐%). Treatment of the <jats:styled-content style="fixed-case">NP</jats:styled-content>s with reducing agent results in the disassembly of the <jats:styled-content style="fixed-case">NP</jats:styled-content>s and release of the drug molecules. A reduction in cell viability is observed at drug concentrations above 250 n<jats:sc>m</jats:sc> in <jats:styled-content style="fixed-case">HEK</jats:styled-content>293T and HeLa cell lines. This drug delivery system has potential for targeting tumor sites <jats:italic>via</jats:italic> the <jats:styled-content style="fixed-case">EPR</jats:styled-content> effect while taking advantage of the increased reduction potential in tumor microenvironment.</jats:p>