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Media type:
E-Article
Title:
A prospective evaluation of the leukocyte adherence inhibition test in colorectal cancer and its correlation with carcinoembryonic antigen levels
Contributor:
Shani, Adi;
Ritts, R. E.;
Thynne, G. S.;
Weiland, Louis H.;
Silvers, Abraham;
Moertel, Charles G.;
Go, V. L. W.
Published:
Wiley, 1978
Published in:
International Journal of Cancer, 22 (1978) 2, Seite 113-119
Description:
AbstractFifty‐four patients from the surgical gastroenterology service and 22 healthy controls have been prospectively evaluated in a single‐blind protocol by the LAI tube method. The LAI correctly identified 25 of 33 early colorectal patients staged as Dukes' B and C at surgery but none of the Dukes' D patients. An inverse relationship was seen between the results of the non‐adherence index (NAI) and CEA levels which was most pronounced in those with advanced colorectal cancer. The majority of Dukes' B and C patients having a “false negative” LAI had a CEA level greater than 2.5 ng/ml, suggesting that more advanced disease than that seen at surgery may be present. Two of 22 normal controls gave a borderline positive NAI. Some technical problems, including the relatively short life of the tumor extracts, are discussed.