> Details

Ranelletti, Franco O.; Scambia, Giovanni; Panici, Pierluigi Benedetti; Piantelu, Mauro; Ferrandina, Gabriella; D'agostino, Giuseppe; De Vincenzo, Rosa; Rinelli, Alessandro; Isola, Giulio; Mancuso, Salvatore

Methyl‐p‐Hydroxyphenyllactate‐esterase activity and type‐II estrogen‐binding sites in ovarian cancer: Correlation with biological and clinico‐pathological parameters

Reference
management

Bookmarks

Remove from
bookmarks

Share this on Whatsapp

Close

Bookmarks



You can manage bookmarks using lists, please log in to your user account for this.
  • Media type: E-Article
  • Title: Methyl‐p‐Hydroxyphenyllactate‐esterase activity and type‐II estrogen‐binding sites in ovarian cancer: Correlation with biological and clinico‐pathological parameters
  • Contributor: Ranelletti, Franco O.; Scambia, Giovanni; Panici, Pierluigi Benedetti; Piantelu, Mauro; Ferrandina, Gabriella; D'agostino, Giuseppe; De Vincenzo, Rosa; Rinelli, Alessandro; Isola, Giulio; Mancuso, Salvatore
  • imprint: Wiley, 1995
  • Published in: International Journal of Cancer
  • Language: English
  • DOI: 10.1002/ijc.2910620508
  • ISSN: 0020-7136; 1097-0215
  • Keywords: Cancer Research ; Oncology
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>We examined the levels of activity of methyl‐p‐hydroxyphenyl‐lactate esterase (MeHPLA‐ase) and cytosolic Type‐II‐estrogen‐binding sites (Type‐II EBS) in 61 and 71 cases, respectively, of primary ovarian cancer. MeHPLA‐ase activity and Type‐II EBS were seen to by asymmetrically distributed, in that levels were skewed towards the lower values. A statistically significant direct correlation was found between MeHPLA‐ase activity and Type‐II EBS. MeHPLA‐ase activity and Type‐II EBS were inversely correlated with ER and PR levels and showed a trend towards inverse correlation with the percentage of cells in S‐phase of the cell cycle. MeHPLA‐ase activity and Type‐II EBS did not correlate with clinico‐pathological parameters. The median MeHPLA‐ase activity tended to be higher in responders than in unresponsive patients, but statistical significance was not reached. Higher Type‐II‐EBS levels were found in cases showing complete and partial response to chemotherapy than in cases which did not respond. A statistically significant relationship was found between high MeHPLA‐ase activity and longer overall survival. © 1995 Wiley‐Liss, Inc.</jats:p>