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Media type:
E-Article
Title:
Synergistic effects of atmospheric pressure plasma‐emitted components on DNA oligomers: a Raman spectroscopic study
Contributor:
Edengeiser, Eugen;
Lackmann, Jan‐Wilm;
Bründermann, Erik;
Schneider, Simon;
Benedikt, Jan;
Bandow, Julia E.;
Havenith, Martina
Published:
Wiley, 2015
Published in:
Journal of Biophotonics, 8 (2015) 11-12, Seite 918-924
Language:
English
DOI:
10.1002/jbio.201400123
ISSN:
1864-063X;
1864-0648
Origination:
Footnote:
Description:
Cold atmospheric‐pressure plasmas have become of increasing importance in sterilization processes especially with the growing prevalence of multi‐resistant bacteria. Albeit the potential for technological application is obvious, much less is known about the molecular mechanisms underlying bacterial inactivation. X‐jet technology separates plasma‐generated reactive particles and photons, thus allowing the investigation of their individual and joint effects on DNA. Raman spectroscopy shows that particles and photons cause different modifications in DNA single and double strands. The treatment with the combination of particles and photons does not only result in cumulative, but in synergistic effects. Profilometry confirms that etching is a minor contributor to the observed DNA damage in vitro.Schematics of DNA oligomer treatment with cold atmospheric‐pressure plasma.magnified imageSchematics of DNA oligomer treatment with cold atmospheric‐pressure plasma.