Pre‐emptive hydration with lactated Ringer's solution could reduce the incidence of post‐endoscopic retrograde cholangiopancreatography pancreatitis in at‐risk patients: Propensity score‐matched analysis
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Media type:
E-Article
Title:
Pre‐emptive hydration with lactated Ringer's solution could reduce the incidence of post‐endoscopic retrograde cholangiopancreatography pancreatitis in at‐risk patients: Propensity score‐matched analysis
Description:
AbstractBackground/PurposeThis study aimed to investigate the efficacy of intensive fluid‐loading therapy post‐endoscopic retrograde cholangiopancreatography (ERCP) for the prevention of post‐ERCP pancreatitis (PEP) in at‐risk patients.MethodsIn this retrospective study, data of 1200 patients at risk for PEP were investigated. After propensity score matching, 404 patients were included in the normal (n = 202) and hydration (n = 202) groups. On the day of ERCP, patients in both groups were infused with 2000 ml/24 h of fluid before ERCP. Meanwhile, the hydration group received an additional 1000 ml/10 h of lactated Ringer's solution postoperatively.ResultsThe incidence of PEP was lower in the hydration group (12.4%) than in the normal group (24.3%) (odds ratio [OR]: 0.44; 95% CI: 0.26–0.75, p = .003). The incidence of severe PEP was 2.0% and 6.9% in the hydration and normal groups (OR: 0.27; 95% CI: 0.09–0.84, p = .027), respectively. The incidence of fatal PEP was 0% and 2.0% in the hydration and normal groups (OR: N.A.: p = .123), respectively.ConclusionsPost‐ERCP hydration may be an effective method of preventing PEP, including severe PEP, in at‐risk patients.