Description:
<jats:title>Abstract</jats:title><jats:p>Tritium labelled splenopentine (Arg‐Lys‐Glu‐Val‐Tyr‐OH) and diacetylsplenopentine (Nα‐ac‐Arg‐Nα‐ac‐Arg‐Nε‐ac‐Lys‐Glu‐Val‐Tyr‐OH) were prepared by the catalytic dehalotritiation of the corresponding diiodopeptides obtained by ICl‐iodination. Under conditious which proved to be optimal in foregoing model deuterations, a specific radioactivity of about 90% of the theoretical one was achieved. The labelling result was influenced noticeably by a transfer of solvent hydrogen directly to the substrate analogously as found in the dehalodeuterations of simple amino acid derivatives.</jats:p>