A new [2H]‐labelled α‐trichloroimidate glucuronic ester for the synthesis of deuterated drug conjugates

Media type: E-Article
Title: A new [2H]‐labelled α‐trichloroimidate glucuronic ester for the synthesis of deuterated drug conjugates
Contributor: Heinkele, Georg; Geditz, Mirjam C. K.; Ganchev, Boian; Kerb, Reinhold; Hofmann, Ute; Mürdter, Thomas E.
imprint: Wiley, 2014
Published in: Journal of Labelled Compounds and Radiopharmaceuticals
Language: English
DOI: 10.1002/jlcr.3243
ISSN: 0362-4803; 1099-1344
Keywords: Organic Chemistry ; Spectroscopy ; Drug Discovery ; Radiology, Nuclear Medicine and imaging ; Biochemistry ; Analytical Chemistry
Origination:
Footnote:
Description: <jats:p>A new reaction pathway for the synthesis of a [<jats:sup>2</jats:sup>H]‐labelled trichloroacetimidate precursor for the preparation of glucuronides is described. Therewith, stable isotope‐labelled drug glucuronides become accessible on a preparative scale, which can further be used as internal standards for quantitative analysis.</jats:p>

Search in field: