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Grazioli, Luigi; Bondioni, Maria Pia; Romanini, Laura; Frittoli, Barbara; Gambarini, Sebastiana; Donato, Francesco; Santoro, Lucia; Colagrande, Stefano

Superparamagnetic iron oxide‐enhanced liver MRI with SHU 555 A (RESOVIST®): New protocol infusion to improve arterial phase evaluation—A prospective study

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  • Media type: E-Article
  • Title: Superparamagnetic iron oxide‐enhanced liver MRI with SHU 555 A (RESOVIST®): New protocol infusion to improve arterial phase evaluation—A prospective study
  • Contributor: Grazioli, Luigi; Bondioni, Maria Pia; Romanini, Laura; Frittoli, Barbara; Gambarini, Sebastiana; Donato, Francesco; Santoro, Lucia; Colagrande, Stefano
  • imprint: Wiley, 2009
  • Published in: Journal of Magnetic Resonance Imaging
  • Language: English
  • DOI: 10.1002/jmri.21644
  • ISSN: 1053-1807; 1522-2586
  • Keywords: Radiology, Nuclear Medicine and imaging
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:sec><jats:title>Purpose</jats:title><jats:p>To compare the arterial enhancement of hypervascular hepatic lesions by T1‐weighted 3D‐GRE (gradient‐recalled echo) fat‐sat sequence after slow (0.5 mL/sec) and fast (2 mL/sec) RESOVIST® infusion.</jats:p></jats:sec><jats:sec><jats:title>Materials and Methods</jats:title><jats:p>We prospectively enrolled 71 patients with hypervascular hepatic lesions to undergo dynamic magnetic resonance imaging (MRI) examination with RESOVIST®. A total of 92 benign and malignant lesions, 44 of which histologically confirmed, were examined. Three blinded and independent readers visually assessed the arterial enhancement using a score from 0 (none) to 3 (maximum), the latter score comparable to that achievable by MultiHance administration.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Out of the 92 hypervascular lesions, 41, 31, and 20 nodules were examined using the slow, fast, and both protocols, respectively. Relevant enhancement (scores 2–3) was found in 42% vs. 14.5% of cases for slow and fast protocols, respectively. Intraindividual comparison evaluation confirmed the better results obtained by slow than fast protocol (25% vs. 10%), with statistically relevant difference in distribution of scores (<jats:italic>P</jats:italic> = 0.0004). The slow protocol showed values between 0 and 3 with an arithmetic mean of 1.1; the fast one, on the other hand, showed values between 0 and 2 with an arithmetic mean of 0.66.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Slow infusion improves arterial enhancement after RESOVIST® administration. J. Magn. Reson. Imaging 2009;29:607–616. © 2009 Wiley‐Liss, Inc.</jats:p></jats:sec>