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Media type:
E-Article
Title:
Prophylactic antibodies inhibit spike‐specific T and B cell responses after COVID‐19 vaccination
Contributor:
Mei, Henrik E.;
Schulz, Axel Ronald;
Hirseland, Heike;
Diekmann, Lisa‐Marie;
Habermann, Elisa;
ten Hagen, Alexander;
Albach, Fredrik;
Burmester, Gerd‐Rüdiger;
Grützkau, Andreas;
Biesen, Robert
Published:
Wiley, 2024
Published in:
Journal of Medical Virology, 96 (2024) 7
Language:
English
DOI:
10.1002/jmv.29778
ISSN:
0146-6615;
1096-9071
Origination:
Footnote:
Description:
AbstractActive and passive immunization is used in high‐risk patients to prevent severe courses of COVID‐19, but the impact of prophylactic neutralizing antibodies on the immune reaction to the mRNA vaccines has remained enigmatic. Here we show that CD4 T and B cell responses to Spikevax booster immunization are suppressed by the therapeutic antibodies Casirivimab and Imdevimab. B cell and T cell responses were significantly induced in controls but not in antibody‐treated patients. The data indicates that humoral immunity, i. e. high levels of antibodies, negatively impacts reactive immunity, resulting in blunted cellular responses upon boosting. This argues for temporal separation of vaccination efforts; with active vaccination preferably applied before prophylactic therapeutic antibody treatment.