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Gentilini, Oreste; Intra, Mattia; Gandini, Sara; Peruzzotti, Giulia; Winnikow, Erik; Luini, Alberto; Veronesi, Paolo; Galimberti, Viviana; Goldhirsch, Aron; Veronesi, Umberto

Ipsilateral breast tumor reappearance in patients treated with conservative surgery after primary chemotherapy. The role of surgical margins on outcome

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  • Media type: E-Article
  • Title: Ipsilateral breast tumor reappearance in patients treated with conservative surgery after primary chemotherapy. The role of surgical margins on outcome
  • Contributor: Gentilini, Oreste; Intra, Mattia; Gandini, Sara; Peruzzotti, Giulia; Winnikow, Erik; Luini, Alberto; Veronesi, Paolo; Galimberti, Viviana; Goldhirsch, Aron; Veronesi, Umberto
  • imprint: Wiley, 2006
  • Published in: Journal of Surgical Oncology
  • Language: English
  • DOI: 10.1002/jso.20583
  • ISSN: 0022-4790; 1096-9098
  • Keywords: Oncology ; General Medicine ; Surgery
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:sec><jats:title>Background and Objectives</jats:title><jats:p>To evaluate the ipsilateral breast tumor reappearance (IBTR) rate after breast conservative surgery (BCS) following primary chemotherapy (PC) and to assess whether positive margins affects IBTR rate and overall survival (OS).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Three hundred nine women candidates for mastectomy received PC before surgery. One hundred ninety‐five patients (63.1%) underwent BCS and 114 patients (36.9%) a modified radical mastectomy.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>After a median follow‐up of 41 months (range 7–90), 13 patients of the 195 treated with BCS had an IBTR (6.7%), 6 patients had a regional relapse (3.1%), 28 women had distant metastases (14.4%). Twenty‐three patients died of breast cancer (11.8%). Twenty‐four patients treated with BCS had positive margins (12.3%). At 3 years, the crude cumulative incidence of local recurrence was 4.7% in women with negative margins, and 13.3% in women with positive margins (<jats:italic>P</jats:italic> = 0.05). Cumulative incidence of distant metastases was similar in patients with positive and negative margins (<jats:italic>P</jats:italic> = 0.16) and there was no significant difference in terms of OS according to the margin status (<jats:italic>P</jats:italic> = 0.577).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>BCS after PC has an acceptable rate of IBTR. After a short follow‐up, the presence of positive margins does not affect OS. J. Surg. Oncol. 2006;94:375–379. © 2006 Wiley‐Liss, Inc.</jats:p></jats:sec>